Independent Research Publications
- “Lewis Acid Mediated Coupling of Silyloxyallylsilanes and Ortholactones: A Convergent, Fragment-Coupling Approach to Functionalized Spiroketals.” Kate L. Marshall and Matthew J. Cook* Submitted for Publication.
Preprint is available on ChemRxiv. DOI: 10.26434/chemrxiv-2022-0mk48
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- “Highly Diastereo- and Branched-Selective Rearrangement of Substituted N-Alloc-N-Allyl Ynamides.” Oliver D. Jackson, Ksenia S. Stankevich and Matthew J. Cook* Chem. Commun. 2022, 58, 11855-11858. DOI: 10.1039/D2CC03399B
- “Design, Synthesis and Biological Evaluation of Novel O-Substituted Tryptanthrin Oxime Derivatives as Potential c-Jun N-terminal Kinase (JNK) Inhibitors.” Igor A. Schepetkin, Anastasia R. Kovrizhina, Ksenia S. Stankevich, Andrei I. Khlebnikov, Liliya N. Kirpotina, Mark T. Quinn* and Matthew J. Cook* Front. Pharmacol. 2022, Accepted for Publication. DOI: 10.3389/fphar.2022.958687
- “A Highly Stereoselective Claisen-Sakurai Approach to Densely Functionalized Cyclopentenols.” Ksenia S. Stankevich and Matthew J. Cook* J. Org. Chem. 2022, 87, 12250-12256. DOI: 10.1021/acs.joc.2c01397
- “Pd-Catalyzed Rearrangement of N-Alloc-N-Allyl Ynamides via Auto-Tandem Catalysis. Evidence for Reversible C-N Activation and Pd(0) Accelerated Ketenimine Aza-Claisen Rearrangement” Juliana R. Alexander, Veronika I. Shchepetkina, Ksenia S. Stankevich, Rory J. Benedict, Samuel P. Bernhard, Reagan J. Dreiling and Matthew J. Cook* Org. Lett. 2021, 23, 559-564. DOI: 10.1021/acs.orglett.0c04078
- “Coumarin Partitioning in Model Biological Membranes: Limitations of LogP as a Predictor” Katelyn M. Duncan, Aoife Casey, Christine A. Gobrogge, Rhys Trousdale, Stefan M. Pointek, Matthew J. Cook, William H. Steel and Robert A. Walker* J. Phys. Chem. B 2020, 124, 8299–8308. DOI: 10.1021/acs.jpcb.0c06109
- “A Highly Selective Bi(OTf)3 Mediated Fragmentation-Contraction of δ-Ortholactones. A Facile Route to Highly Functionalized γ-Lactones” Kate L. Baddeley and Matthew J. Cook*, Tetrahedron, 2018, 74, 5172-5182. DOI: 10.1016/j.tet.2018.04.055
Invited contribution: for the Sir Derek Barton Centennial Edition of Tetrahedron.
- “Formation of Ketenimines via the Palladium Catalyzed Decarboxylative π-Allylic Rearrangement of N-Alloc Ynamides” Juliana R. Alexander and Matthew J. Cook*, Org. Lett. 2017, 19, 5822–5825. DOI: 10.1021/acs.orglett.7b02780
- “A Hydrosilylation-Hiyama Approach to Highly Functionalized Dienes” Catherine A. McAdam, Mark G. McLaughlin and Matthew J. Cook*, Org. Chem. Front. 2015, 2, 510-514. DOI: 10.1039/C5QO00002E
Invited Contribution: for the Negishi (Nobel Laureate) 80th Birthday Edition.
- “Palladium Catalyzed Oxidative Synthesis of Highly Functionalized Ortholactones” Kate L. Baddeley, Qun Cao, Mark J. Muldoon*, and Matthew J. Cook* Chem. Eur. J. 2015, 21, 7726-7730. DOI: 10.1002/chem.201500862
- “Base Mediated Cascade Rearrangements of Aryl Substituted Diallyl Ethers” Jolene P. Reid, Catherine A. McAdam, Adam, J. S. Johnston, Matthew N. Grayson, Jonathan M. Goodman and Matthew J. Cook*, J. Org. Chem. 2015, 80, 1472-1498. DOI: 10.1021/jo502403n
Highlighted in: Organic Chemistry Portal.
- “MIDA Vinylsilanes: Selective Cross-Couplings and Applications to the Synthesis of Functionalized Stilbenes” Mark G. McLaughlin, Catherine A. McAdam and Matthew J. Cook*, Org. Lett. 2015, 17, 10-13. DOI: 10.1021/ol503065a
Highlighted in: Organic Chemistry Portal.
- “Silicon-Directed Rhenium Catalyzed Allylic Substitutions with N-Hydroxycarbamates, N-Hydroxysulfonamides and Hydroxamic Acids” Sanjay W. Chavhan, Catherine A. McAdam and Matthew J. Cook* J. Org. Chem. 2014, 79, 11234-11240. DOI: 10.1021/jo501992p
- “Silicon-Directed Rhenium Catalyzed Allylic Carbaminations and Oxidative Fragmentations of γ-Silyl Allylic Alcohols” Sanjay W. Chanvhan and Matthew J. Cook*, Chem. Eur. J. 2014, 20, 4891-4895. DOI: 10.1002/chem.201400104
- “Highly Diastereoselective Hydrosilylations of Allylic Alcohols” Mark. G. McLaughlin and Matthew J. Cook* Chem. Commun. 2014, 50, 3501-3504. DOI: 10.1039/C4CC00138A
- “NaH Mediated Isomerisation-Allylation Reaction of 1,3-Substituted Propenols” Adam J. S. Johnston, Mark G. McLaughlin, Jolene P. Reid and Matthew J. Cook*, Org. Biomol. Chem. 2013, 11, 7662-7666. DOI: 10.1039/C3OB41857J (Open Access)
- “The Synthesis of Nitriles from Aldehydes and Aqueous Ammonia Catalysed by Copper(II)/TEMPO with Ambient Air as the Oxidant” Laura M. Dornan, Qun Cao, James C. A. Flanagan, James, J. Crawford, Matthew J. Cook* and Mark J. Muldoon*, Chem. Commun. 2013, 49, 6030 -6032. DOI: 10.1039/C3CC42231C
Highlighted in: Org. Proc. Res. Dev. 2013, 17, 994-1001.
- “Platinum Catalysed Hydrosilylation of Propargylic Alcohols” Catherine A. McAdam, Mark G. McLaughlin, Adam J. S. Johnston, Jun Chen, Magnus W. Walter and Matthew J. Cook*, Org. Biomol. Chem. 2013, 11, 4488 – 4502. DOI: 10.1039/C3OB40496J (Open Access)
- “Palladium Catalyzed Decarboxylative Rearrangement of N-Alloc Indoles” Jun Chen and Matthew J. Cook*, Org. Lett. 2013, 15, 1088-1091. DOI: 10.1021/ol400110c
- “The Synthesis of N-Heterocycles via Copper/TEMPO Catalysed Aerobic Oxidation of Amino Alcohols” James C. A. Flanagan, Laura M. Dornan, Mark G. McLaughlin, Niall G. McCreanor, Matthew J. Cook* and Mark J. Muldoon*, Green Chem. 2012, 14, 1281. DOI: 10.1039/C2GC35062A (Open Access)
- “Domino Alkene-Isomerization-Claisen Rearrangement Strategy to Substituted Allylsilanes” Mark G. McLaughlin and Matthew J. Cook*, J. Org. Chem. 2012, 77, 2058. DOI: 10.1021/jo202560g
Highlighted in: Synfacts 2012, 8, 527.
- “PtCl2/XPhos: A highly efficient and readily available catalyst for the hydrosilylation of propargylic alcohols” Mark G. McLaughlin and Matthew J. Cook*, Chem. Comm. 2011, 47, 11104-11106. DOI: 10.1039/C1CC14433B
Independent Review Publications
- “meso-3,5-Dimethyl Glutaric Anhydride” Matthew J. Cook* e-EROS: Encyclopedia of Reagents for Organic Synthesis, 2018, DOI: 10.1002/047084289X.rn02080. Link
- 4-Fluorostyrene” Niall G. McCreanor and Matthew J. Cook*, e-EROS: Encyclopedia of Reagents for Organic Synthesis 2012, DOI: 10.1002/047084289X.rn01450. Link
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“4-Trifluoromethylstyrene” Mark. G. McLaughlin and Matthew J. Cook*, e-EROS: Encyclopedia of Reagents for Organic Synthesis 2012, DOI: 10.1002/047084289X.rn01451. Link
Graduate and Postdoctoral Publications
- “The Catalytic Alkylative Desymmetrization of Anhydrides in a Formal Synthesis of Ionomycin” Kevin M. Oberg; Brian M. Cochran; Matthew J. Cook and Tomislav Rovis*, Synthesis 2018, 50, In Press. DOI: 10.1055/s-0037-1609733. Link
Invited Contribution: for the Scott Denmark 65th Birthday Edition of Synthesis
- “Processes for Preparing 5,7-Diaminopyrazolo[1,5-a] Pyrimidine Compounds” Dennis C. Liotta; James P. Snyder.; Ashutosh S. Jogalekar; Anthony G. M. Barrett; Matthew J. Fuchter; Matthew J. Cook; Sebastian H. B. Kroll, PTC Int. Appl. 2010, WO 2010/069938 A2 20100617. Link
- “Ligand Differentiated Complemtary Rh Catalysts for the Enantioselective Desymmetrization of meso Cyclic Anhydrides” Jeffrey B. Johnson, Matthew J. Cook and Tomislav Rovis*, Tetrahedron 2009, 65, 3202-3210. Link
Invited contribution: for the Tetrahedron Young Investigator Award 2008 to Professor Justin Du Bois.
- “Enantioselective Rhodium-Catalyzed Alkylative Desymmetrization of 3,5-Dimethylglutaric Anhydride” Matthew J. Cook and Tomislav Rovis*, Synthesis 2009, 335-338. Link
- “Enantioslective Rhodium Catalyzed Desymmetrization of meso-3,5-Dimethyl Glutaric Anhydride: A General Strategy to syn-Polypropionate Synthons” Matthew J. Cook and Tomislav Rovis*, J. Am. Chem. Soc. 2007, 129, 9302-9303. Link
Highlighted in: Chem. & Ind. 2007, (16), 29-30 and Synfacts 2007, 10, 1053. Selected as: “Synfact of the Month” for Oct. 2007 & review of this work was published in Synform 2007, A81.
- “Microwave-Assisted, Regioselective, Petasis Olefination of Unsymmetrical Oxalates. Formation of Pyruvate Based Enol Ethers and enamines” Matthew J. Cook, Declan, W. Fleming and Timothy Gallagher*, Tetrahedron Lett. 2005, 46, 297-300. Link
- “Highly Stereoselective Addition of Organozinc Reagents to Pentopyranose Derived Glycals: Effect of Protecting Group and Assignment of C-Glycoside Stereochemistry” Matthew J. Cook, Matthew J. E. Fletcher, Diane Gray, Peter J. Lovell and Timothy Gallagher*, Tetrahedron, 2004, 60, 5085-5092. Link