Independent Research Publications

  1. “Lewis Acid Mediated Coupling of Silyloxyallylsilanes and Ortholactones: A Convergent, Fragment-Coupling Approach to Functionalized Spiroketals.” Kate L. Marshall and Matthew J. Cook* Submitted for Publication. 

    Preprint is available on ChemRxiv. DOI: 10.26434/chemrxiv-2022-0mk48

    Graphic Coming Soon

  2. “Highly Diastereo- and Branched-Selective Rearrangement of Substituted N-Alloc-N-Allyl Ynamides.” Oliver D. Jackson, Ksenia S. Stankevich and Matthew J. Cook* Chem. Commun. 202258, 11855-11858. DOI: 10.1039/D2CC03399B


  3. “Design, Synthesis and Biological Evaluation of Novel O-Substituted Tryptanthrin Oxime Derivatives as Potential c-Jun N-terminal Kinase (JNK) Inhibitors.” Igor A. Schepetkin, Anastasia R. Kovrizhina, Ksenia S. Stankevich, Andrei I. Khlebnikov, Liliya N. Kirpotina, Mark T. Quinn* and Matthew J. Cook* Front. Pharmacol. 2022, Accepted for Publication. DOI: 10.3389/fphar.2022.958687

  4. “A Highly Stereoselective Claisen-Sakurai Approach to Densely Functionalized Cyclopentenols.” Ksenia S. Stankevich and Matthew J. Cook* J. Org. Chem. 2022, 87, 12250-12256. DOI: 10.1021/acs.joc.2c01397


  5. “Pd-Catalyzed Rearrangement of N-Alloc-N-Allyl Ynamides via Auto-Tandem Catalysis. Evidence for Reversible C-N Activation and Pd(0) Accelerated Ketenimine Aza-Claisen Rearrangement” Juliana R. Alexander, Veronika I. Shchepetkina, Ksenia S. Stankevich, Rory J. Benedict, Samuel P. Bernhard, Reagan J. Dreiling and Matthew J. Cook* Org. Lett. 2021, 23, 559-564. DOI: 10.1021/acs.orglett.0c04078


  6. “Coumarin Partitioning in Model Biological Membranes: Limitations of LogP as a Predictor” Katelyn M. Duncan, Aoife Casey, Christine A. Gobrogge, Rhys Trousdale, Stefan M. Pointek, Matthew J. Cook, William H. Steel and Robert A. Walker* J. Phys. Chem. B 2020, 124, 8299–8308. DOI: 10.1021/acs.jpcb.0c06109

    JPCB 2020

  7. “A Highly Selective Bi(OTf)3 Mediated Fragmentation-Contraction of δ-Ortholactones. A Facile Route to Highly Functionalized γ-Lactones” Kate L. Baddeley and Matthew J. Cook*, Tetrahedron, 2018, 74, 5172-5182. DOI:  10.1016/j.tet.2018.04.055

    Invited contribution: for the Sir Derek Barton Centennial Edition of Tetrahedron.

    Bi(OTf)3 Tetrahedron Graphical Abstract 1

  8. “Formation of Ketenimines via the Palladium Catalyzed Decarboxylative π-Allylic Rearrangement of N-Alloc Ynamides” Juliana R. Alexander and Matthew J. Cook*, Org. Lett. 201719, 5822–5825. DOI: 10.1021/acs.orglett.7b02780

    ketenimine GA

  9. “A Hydrosilylation-Hiyama Approach to Highly Functionalized Dienes” Catherine A. McAdam, Mark G. McLaughlin and Matthew J. Cook*, Org. Chem. Front. 20152, 510-514. DOI: 10.1039/C5QO00002E

    Invited Contribution: for the Negishi (Nobel Laureate) 80th Birthday Edition.

    org chem front 2015

  10. “Palladium Catalyzed Oxidative Synthesis of Highly Functionalized Ortholactones” Kate L. Baddeley, Qun Cao, Mark J. Muldoon*, and Matthew J. Cook* Chem. Eur. J. 201521, 7726-7730. DOI: 10.1002/chem.201500862

    CEJ 2015

  11. “Base Mediated Cascade Rearrangements of Aryl Substituted Diallyl Ethers” Jolene P. Reid, Catherine A. McAdam, Adam, J. S. Johnston, Matthew N. Grayson, Jonathan M. Goodman and Matthew J. Cook*, J. Org. Chem. 201580, 1472-1498. DOI: 10.1021/jo502403n

    Highlighted in: Organic Chemistry Portal.

    JOC 2015

  12. “MIDA Vinylsilanes: Selective Cross-Couplings and Applications to the Synthesis of Functionalized Stilbenes” Mark G. McLaughlin, Catherine A. McAdam and Matthew J. Cook*, Org. Lett. 201517, 10-13. DOI: 10.1021/ol503065a

    Highlighted in: Organic Chemistry Portal.

    OL 2015

  13. “Silicon-Directed Rhenium Catalyzed Allylic Substitutions with N-Hydroxycarbamates, N-Hydroxysulfonamides and Hydroxamic Acids” Sanjay W. Chavhan, Catherine A. McAdam and Matthew J. Cook* J. Org. Chem. 201479, 11234-11240. DOI: 10.1021/jo501992p

    CEJ 2015

  14. “Silicon-Directed Rhenium Catalyzed Allylic Carbaminations and Oxidative Fragmentations of γ-Silyl Allylic Alcohols” Sanjay W. Chanvhan and Matthew J. Cook*, Chem. Eur. J. 201420, 4891-4895. DOI: 10.1002/chem.201400104

    CEJ 2014

  15. “Highly Diastereoselective Hydrosilylations of Allylic Alcohols” Mark. G. McLaughlin and Matthew J. Cook*  Chem. Commun. 201450, 3501-3504. DOI: 10.1039/C4CC00138A   

    CC 2014

  16. “NaH Mediated Isomerisation-Allylation Reaction of 1,3-Substituted Propenols” Adam J. S. Johnston, Mark G. McLaughlin, Jolene P. Reid and Matthew J. Cook*, Org. Biomol. Chem. 201311, 7662-7666. DOI: 10.1039/C3OB41857J (Open Access)

    OBC 2013 B

  17. “The Synthesis of Nitriles from Aldehydes and Aqueous Ammonia Catalysed by Copper(II)/TEMPO with Ambient Air as the Oxidant” Laura M. Dornan, Qun Cao, James C. A. Flanagan, James, J. Crawford, Matthew J. Cook* and Mark J. Muldoon*, Chem. Commun. 2013, 49, 6030 -6032. DOI: 10.1039/C3CC42231C 

    Highlighted in: Org. Proc. Res. Dev. 201317, 994-1001.

    CC 2013

  18. “Platinum Catalysed Hydrosilylation of Propargylic Alcohols” Catherine A. McAdam, Mark G. McLaughlin, Adam J. S. Johnston, Jun Chen, Magnus W. Walter and Matthew J. Cook*, Org. Biomol. Chem. 201311, 4488 – 4502. DOI: 10.1039/C3OB40496J (Open Access)

    OBC2013 A

  19. “Palladium Catalyzed Decarboxylative Rearrangement of N-Alloc Indoles” Jun Chen and Matthew J. Cook*, Org. Lett. 2013, 15, 1088-1091. DOI: 10.1021/ol400110c

    OL 2013

  20. “The Synthesis of N-Heterocycles via Copper/TEMPO Catalysed Aerobic Oxidation of Amino Alcohols” James C. A. Flanagan, Laura M. Dornan, Mark G. McLaughlin, Niall G. McCreanor, Matthew J. Cook* and Mark J. Muldoon*, Green Chem. 2012, 14, 1281. DOI: 10.1039/C2GC35062A (Open Access)

    GC 2012

  21. “Domino Alkene-Isomerization-Claisen Rearrangement Strategy to Substituted Allylsilanes” Mark G. McLaughlin and Matthew J. Cook*, J. Org. Chem. 2012, 77, 2058. DOI: 10.1021/jo202560g

    Highlighted in: Synfacts 2012, 8, 527.

    JOC 2012

  22. “PtCl2/XPhos: A highly efficient and readily available catalyst for the hydrosilylation of propargylic alcohols”  Mark G. McLaughlin and Matthew J. Cook*, Chem. Comm. 2011, 47, 11104-11106. DOI: 10.1039/C1CC14433B

    CC 2011

    Independent Review Publications

  23. “meso-3,5-Dimethyl Glutaric Anhydride” Matthew J. Cook* e-EROS: Encyclopedia of Reagents for Organic Synthesis, 2018, DOI: 10.1002/047084289X.rn02080. Link

  24. 4-Fluorostyrene” Niall G. McCreanor and Matthew J. Cook*, e-EROS: Encyclopedia of Reagents for Organic Synthesis 2012, DOI: 10.1002/047084289X.rn01450. Link

  25. “4-Trifluoromethylstyrene” Mark. G. McLaughlin and Matthew J. Cook*, e-EROS: Encyclopedia of Reagents for Organic Synthesis 2012DOI: 10.1002/047084289X.rn01451. Link

    Graduate and Postdoctoral Publications

  26. “The Catalytic Alkylative Desymmetrization of Anhydrides in a Formal Synthesis of Ionomycin” Kevin M. Oberg; Brian M. Cochran; Matthew J. Cook and Tomislav Rovis*, Synthesis 201850, In PressDOI: 10.1055/s-0037-1609733. Link

    Invited Contribution:  for the Scott Denmark 65th Birthday Edition of Synthesis

  27. “Processes for Preparing 5,7-Diaminopyrazolo[1,5-a] Pyrimidine Compounds” Dennis C. Liotta; James P. Snyder.; Ashutosh S. Jogalekar; Anthony G. M. Barrett; Matthew J. Fuchter; Matthew J. Cook; Sebastian H. B. Kroll, PTC Int. Appl. 2010, WO 2010/069938 A2 20100617. Link

  28. “Ligand Differentiated Complemtary Rh Catalysts for the Enantioselective Desymmetrization of meso Cyclic Anhydrides” Jeffrey B. Johnson, Matthew J. Cook and Tomislav Rovis*, Tetrahedron 2009, 65, 3202-3210. Link 

    Invited contribution: for the Tetrahedron Young Investigator Award 2008 to Professor Justin Du Bois.

  29. “Enantioselective Rhodium-Catalyzed Alkylative Desymmetrization of 3,5-Dimethylglutaric Anhydride”  Matthew J. Cook and Tomislav Rovis*, Synthesis 2009, 335-338. Link

  30. “Enantioslective Rhodium Catalyzed Desymmetrization of meso-3,5-Dimethyl Glutaric Anhydride: A General Strategy to syn-Polypropionate Synthons” Matthew J. Cook and Tomislav Rovis*, J. Am. Chem. Soc. 2007, 129, 9302-9303. Link 

    Highlighted in: Chem. & Ind. 2007, (16), 29-30 and Synfacts 2007, 10, 1053. Selected as: “Synfact of the Month” for Oct. 2007 & review of this work was published in Synform 2007, A81.

  31. “Microwave-Assisted, Regioselective, Petasis Olefination of Unsymmetrical Oxalates. Formation of Pyruvate Based Enol Ethers and enamines” Matthew J. Cook, Declan, W. Fleming and Timothy Gallagher*, Tetrahedron Lett. 2005, 46, 297-300. Link

  32. “Highly Stereoselective Addition of Organozinc Reagents to Pentopyranose Derived Glycals: Effect of Protecting Group and Assignment of C-Glycoside Stereochemistry” Matthew J. Cook, Matthew J. E. Fletcher, Diane Gray, Peter J. Lovell and Timothy Gallagher*, Tetrahedron, 2004, 60, 5085-5092. Link